Explore Our Science
Dive into how our in vitro models and growth
enhancers replicate key body environments to support microbiome research and product development.
Results
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Advanced in vitro model for culturing cervicovaginal microbiota
Advanced in vitro model for intestinal microbiota culture
Bac3Beads: Spherically shaped mucin-based growth booster beads
Advanced in vitro model for airway microbiota culture
Publications
Air3Gel
O.V. Garbero, L. Sardelli, C.S. Butnarasu, E. Frasca, C. Medana, F. Dal Bello, S. Visentin. (2024). Tracing the path of Quorum sensing molecules in cystic fibrosis mucus in a biomimetic in vitro permeability platform. Scientific Reports, 14(1): 25907.
C.S. Butnarasu, O.V. Garbero, P. Petrini, L. Visai, Sonja Visentin. (2023). Permeability Assessment of a High-Throughput Mucosal Platform. Pharmaceutics, 15(2):380.
C.S. Butnarasu, P. Petrini, F. Bracotti, L. Visai, G. Guagliano, A. Fiorio Pla, E. Sansone, S. Petrillo, S. Visentin. (2022). Mucosomes: Intrinsically Mucoadhesive Glycosylated Mucin Nanoparticles as Multi-Drug Delivery Platform. Advanced Healthcare Materials, 11(15): e2200340.
D. P. Pacheco, F. Bertoglio, C.S. Butnarasu, N. Suárez Vargas, G. Guagliano, A. Ziccarelli, F. Briatico-Vangosa, V. Ruzzi, S. Buzzaccaro, R. Piazza, S. van Uden, E. Crotti, S. Visentin, L. Visai, P. Petrini. (2023). Heterogeneity Governs 3D-Cultures of Clinically Relevant Microbial Communities. Advanced Healthcare Materials.
D. P. Pacheco, C.S. Butnarasu, F. Briatico-Vangosa, L. Pastorino, L. Visai, S. Visentin, P. Petrini. (2019). Disassembling the complexity of mucus barriers to develop a fast screening tool for early drug discovery. Journal of Materials Chemistry B., 7, 4940-4952.
C.S. Butnarasu, N. Barbero, D. P. Pacheco, P. Petrini, S. Visentin. (2019). Mucin binding to therapeutic molecules: The case of antimicrobial agents used in cystic fibrosis. Int J Pharm, 564:136-144.
C.S. Butnarasu, G. Caron, D. P. Pacheco, P. Petrini, S. Visentin. (2022). Cystic Fibrosis Mucus Model to Design More Efficient Drug Therapies. Mol Pharm, 19(2): 520-531.
L. Pedersoli, S. Zhang, F. Briatico-Vangosa, P. Petrini, R. Cardinaels, J. den Toonder, D. P. Pacheco. (2021). Engineered modular microphysiological models of the human airway clearance phenomena. Biotechnol Bioeng, 118(10): 3898-3913.
Gut3Gel
Vargas, N. S., Antunes, M., Sobral, J., Silva, C., Sousa, F., Garbero, O. V., Kolková, A., Visai, L., Medana, C., Visentin, S., Petrini, P., van Uden, S., Pacheco, D. (2025). Gut3Gel: A High Throughput Mucus Model to Support Intestinal Microbiome Research. Gut Microbiology, 2025, 100003.
Antunes, M., Jongen, L., Mateen, A., Sobral, J., van Uden, S., Vargas, N. S., & Pacheco, D. (2025). Gut3Gel as an in vitro model to investigate dietary modulation of the intestinal microbiota: An inulin supplementation case study. bioRxiv, 2025-05.