Colonic-like mucus model replicating the composition, structure, and barrier properties of healthy human colon mucus.
Composed of:
- 50.0 mg/ml mucin
- 0.57 mg/ml NaCl
Native-like small intestinal mucus model mimicking the composition and viscoelasticity of healthy human small intestine mucus.
Composed of:
- 14.2 mg/ml mucin
- 0.07 mg/ml NaCl
Advantages
Replicates the natural composition and properties of intestinal mucus
Drug permeability studies, bacterial colonization research, microbiota growth, targeted evaluation of drug efficacy for intestinal applications, and microbiome mining
Standardized, reproducible, and ready-to-use mucus models that accelerates high-throughput drug and microbiome research and seamlessly integrates into existing workflows—saving time and streamlining discovery
Reduce the need for animal testing by mimicking human mucus, aligning with ethical and regulatory principles
Publications
Vargas, N. S., Antunes, M., Sobral, J., Silva, C., Sousa, F., Garbero, O. V., Kolková, A., Visai, L., Medana, C., Visentin, S., Petrini, P., van Uden, S., Pacheco, D. (2025). Gut3Gel: A High Throughput Mucus Model for Culturing Human Intestinal Microbiota. bioRxiv, 2025-02.
Antunes, M., Jongen, L., Mateen, A., Sobral, J., van Uden, S., Vargas, N. S., & Pacheco, D. (2025). Gut3Gel as an in vitro model to investigate dietary modulation of the intestinal microbiota: An inulin supplementation case study. bioRxiv, 2025-05.