Bioinspired chemistry

Our substrates took inspiration from the human mucus, the place where microorganisms live in our body.

Mucin

Tuneable composition to include:

Proteins
DNA
Lipids

Partners

The vast majority of microorganisms are not culturable in vitro.
By copying key properties of the human mucus, Bac3Gel® provides advanced 3D substrates exhibiting micro-gradients for the culture of microorganisms.
It is now possible to sustain different microbiota in the laboratory to generate and test new solutions for healthcare and wellness.
Politecnico di Milano
University of Turin
University of Pavia
Partner 4
Partner 5
Partner 6
Partner 7
Partner 8
about us
Harness the power
of bacteria
CHALLENGES IN MICROBIOLOGY
78% of known bacteria species
98% of unknown bacteria species
Multiple bacteria species together
are not culturable in the lab
available culture methods
are not representative
Planktonic
Agar Plates
Bioreactors
Animal Models
Human mucus
the perfect culturing substrate
Because that's where bacteria live in the human body*
*The vast majority
Modelling the human mucus in vitro

The human mucus varies chemically and structurally over three domains: across itself - apical-basolateral axis, between the different body districts - lung, stomach, intestine, cervico-vaginal, among others, and between states - physiological or pathological, fed or fasting, ovulation or pregnancy. Some mucus contain a gradient of oxygen and nutrients which deeply affects bacteria behaviour. These conditions where taken into account as a target while developing each Bac3Gel model.

Human mucus as a filter

The human mucus functions as a filter for any agent that is able to reach it and attempts to cross it. The objective is to protect the epithelium and the whole system from harmful substances and pathogens. It works in tandem with the immune system by entrapping and expelling harmful agents. Sometimes micro-organisms and human cells suffer necrosis and release DNA across the mucus influencing it behaviour, mucus models should be able account for it.

ENABLING TECHNOLOGY
TO HARNESS THE POWER OF BACTERIA
Artificial human mucus
Patented technology
Fully Tuneable
Adapt to recreate
different micro-organism communities
Modelling the human mucus in vitro

The human mucus varies chemically and structurally over three domains: across itself - apical-basolateral axis, between the different body districts - lung, stomach, intestine, cervico-vaginal, among others, and between states - physiological or pathological, fed or fasting, ovulation or pregnancy. Some mucus contain a gradient of oxygen and nutrients which deeply affects bacteria behaviour. These conditions where taken into account as a target while developing each Bac3Gel model.

Human mucus as a filter

The human mucus functions as a filter for any agent that is able to reach it and attempts to cross it. The objective is to protect the epithelium and the whole system from harmful substances and pathogens. It works in tandem with the immune system by entrapping and expelling harmful agents. Sometimes micro-organisms and human cells suffer necrosis and release DNA across the mucus influencing it behaviour, mucus models should be able account for it.

Bac3Gel® Lda

VAT: PT516010085
Address
Av. Jacques Delors 411 Lab 2
2740-122 Porto Salvo - Portugal
Phone
(+351) 918658193 / (+351) 918236302
Email
contact@bac3gel.com